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Calpain Inhibitor XII
CAS No. 181769-57-3
Calpain Inhibitor XII( —— )
Catalog No. M33772 CAS No. 181769-57-3
Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | Get Quote |
|
| 5MG | 353 | Get Quote |
|
| 10MG | 521 | Get Quote |
|
| 25MG | 799 | Get Quote |
|
| 50MG | 1076 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCalpain Inhibitor XII
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NoteResearch use only, not for human use.
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Brief DescriptionCalpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B.
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Description(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetCysteine Protease
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RecptorCysteine Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number181769-57-3
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Formula Weight482.57
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Molecular FormulaC26H34N4O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16 mg/mL (33.16 mM)
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SMILESO=C(OCC=1C=CC=CC1)NC(C(=O)NC(C(=O)C(=O)NCC2=NC=CC=C2)CCC)CC(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Z Li, et al. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem. 1996 Sep 27;39(20):4089-98.?
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