Calpain Inhibitor XII

Research use only, not for human use.

Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B.

(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

——

——

——

Proteasome/Ubiquitin

Cysteine Protease

Cysteine Protease

——

——

181769-57-3

482.57

C26H34N4O5

>98% (HPLC)

In Vitro:?DMSO : 16 mg/mL (33.16 mM)

O=C(OCC=1C=CC=CC1)NC(C(=O)NC(C(=O)C(=O)NCC2=NC=CC=C2)CCC)CC(C)C

——

(-20℃)

With Ice Pack

≥ 2 years